[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetic acid
Phenylacetic acid-4-boronic acid pinacol ester
CAS: 797755-07-8
Molecular Formula: C14H19BO4
[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetic acid - Names and Identifiers
[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetic acid - Physico-chemical Properties
| Molecular Formula | C14H19BO4 |
| Molar Mass | 262.11 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Melting Point | 165-170°C |
| Boling Point | 398.2±25.0 °C(Predicted) |
| Appearance | Crystalline Powder or Powder |
| Color | White to yellow |
| pKa | 4.24±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 1 |
| Hazard Class | IRRITANT |
[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetic acid - Introduction
Phenylacetic acid-4-boronic acid pinacol ester is an organic compound with the chemical formula C14H19BO4.
Nature:
1. Appearance: white solid.
2. solubility: soluble in organic solvents such as dichloromethane, ethanol and methanol, insoluble in water.
3. melting point: about 78-82 degrees Celsius.
Use:
1. Phenylacetic acid-4-boronic acid pinacol ester is a commonly used organic synthesis reagent, which can be used to synthesize various organic compounds containing acyl groups, such as ketones and aldehydes.
2. In drug synthesis, it can be used to prepare intermediates for certain drugs.
3. can also be applied to heterocyclic synthesis and carbon-carbon or carbon-heteroatom bond construction reaction.
Preparation Method:
Phenylacetic acid-4-boronic acid pinacol ester is usually synthesized by esterification. The specific steps include reacting phenylacetic acid with 4-hydroxyphenylboronic acid amide, then adding a certain amount of pinacol as an esterification reaction reagent, and obtaining the target product through crystallization and purification after the reaction.
Safety Information:
Phenylacetic acid-4-boronic acid pinacol ester is generally stable under normal use conditions, it should avoid contact with oxidants, strong acids, strong bases and other substances. During operation, necessary personal protective measures should be taken, such as wearing masks, gloves and goggles.
Nature:
1. Appearance: white solid.
2. solubility: soluble in organic solvents such as dichloromethane, ethanol and methanol, insoluble in water.
3. melting point: about 78-82 degrees Celsius.
Use:
1. Phenylacetic acid-4-boronic acid pinacol ester is a commonly used organic synthesis reagent, which can be used to synthesize various organic compounds containing acyl groups, such as ketones and aldehydes.
2. In drug synthesis, it can be used to prepare intermediates for certain drugs.
3. can also be applied to heterocyclic synthesis and carbon-carbon or carbon-heteroatom bond construction reaction.
Preparation Method:
Phenylacetic acid-4-boronic acid pinacol ester is usually synthesized by esterification. The specific steps include reacting phenylacetic acid with 4-hydroxyphenylboronic acid amide, then adding a certain amount of pinacol as an esterification reaction reagent, and obtaining the target product through crystallization and purification after the reaction.
Safety Information:
Phenylacetic acid-4-boronic acid pinacol ester is generally stable under normal use conditions, it should avoid contact with oxidants, strong acids, strong bases and other substances. During operation, necessary personal protective measures should be taken, such as wearing masks, gloves and goggles.
Last Update：2024-04-09 02:00:56
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